Description CJC-1295 represents a sophisticated synthetic analogue of human growth hormone-releasing hormone, engineered through strategic amino acid substitutions to optimize stability and research utility. The compound exhibits the molecular formula C165H269N47O46 with a molecular weight of 3647.15 g/mol and is catalogued under CAS number 446036-97-1. The structural modifications incorporated into CJC-1295 include D-alanine at position 2 to enhance resistance to enzymatic degradation, glutamine at position 8 to reduce asparagine rearrangement and prevent amide hydrolysis to aspartic acid, alanine at position 15 to enhance bioactivity, and leucine at position 27 to prevent methionine oxidation. CJC-1295 is available in two primary formulations for research purposes: the standard form without Drug Affinity Complex and CJC-1295 DAC, which incorporates a maleimidopropionic acid-lysine modification at the C-terminus. Both formulations are classified as growth hormone secretagogues and function through interaction with growth hormone-releasing hormone receptors in laboratory systems. For research use only.
