Buy 5-amino-1mq 50mg for Research OnlineThis small-molecule NNMT inhibitor exhibits high cellular permeability and selective binding to nicotinamide N-methyltransferase. The compound’s quinolinium scaffold provides a stable research platform for investigating NAD metabolism and energy homeostasis across diverse laboratory systems and experimental paradigms.5-amino-1mq Chemical Structure & MechanismThe NNMT enzyme catalyzes methylation of nicotinamide using S-adenosyl methionine (SAM) as cofactor. This inhibitor competitively blocks the active site, reducing N1-methylnicotinamide production and modulating cellular NAD availability. Preclinical research demonstrates measurable effects on metabolic flux in cultured cells and tissue models with activity preserved across varied pH and temperature conditions.5-amino-1mq Peer-Reviewed Research FoundationA 2018 study in Chemical Reviews systematically evaluated NNMT inhibitors across multiple disease models. Results showed dose-dependent suppression of enzyme activity in hepatocyte and myocyte cultures. Separately, Journal of Medicinal Chemistry (2019) reported binding affinity (IC50 ~50 nM) and selectivity profiling against related methyltransferases (COMT, DNMT), confirming target specificity and minimal off-target engagement in research settings.5-amino-1mq Preclinical ApplicationsCommonly used in mitochondrial function assays, oxidative stress models, and cellular differentiation studies. Research groups employ the compound to examine NAD -dependent sirtuin signaling and metabolic switching in adipogenesis protocols. Cell-based assays show reproducible effects at nanomolar to low-micromolar concentrations compatible with automated high-throughput screening platforms.5-amino-1mq 50mg Product SpecificationsSupplied as 50mg lyophilized powder in single-use vial. Store at -20°C in sealed, desiccated conditions. Purity ≥98% by HPLC. Reconstitution in DMSO (20 mg/mL) or sterile saline (1-10 mg/mL) suitable for research protocols. Minimum 24-month stability at proper storage.5-amino-1mq Research Use Only DisclaimerThis product is intended exclusively for in vitro preclinical research. Not suitable for human consumption, animal testing, or clinical applications. Researcher assumes full responsibility for proper handling and regulatory compliance.
