Buy ARA-290 10mg Research Peptide OnlineARA-290 (Cibinetide) is a synthetic 11-amino-acid peptide derived from erythropoietin’s tissue-protective domain. The peptide activates the innate repair receptor (IRR), a non-hematopoietic erythropoietin receptor variant studied in preclinical models of cellular stress, inflammation, and cytoprotection.ARA-290 Structural Origin & MechanismThis peptide corresponds to the C-terminal region of human erythropoietin (amino acids 165-175) and activates IRR signaling without engaging the classic erythropoietin receptor (EpoR) involved in hematopoiesis. Preclinical research in cultured neurons, macrophages, and epithelial cells demonstrates anti-inflammatory effects and enhanced cellular survival under stress conditions through JAK/STAT and MAPK activation.ARA-290 Published Preclinical ResearchThe FASEB Journal (2008) first characterized IRR signaling and ARA-290’s activation of JAK/STAT pathways in cultured macrophages, reducing pro-inflammatory cytokine release (TNF-α, IL-6). Shock (2011) demonstrated the peptide’s cytoprotective effects in lipopolysaccharide-treated cell models and tissue explants. Cytokine (2014) further established that ARA-290 engaged MAPK and PI3K signaling cascades associated with cellular survival and reduced apoptosis markers.ARA-290 Preclinical ApplicationsEmployed in neuroinflammation models, innate immune cell culture systems, tissue injury protocols, and cellular stress-response assays. Researchers apply ARA-290 to investigate IRR signaling, anti-inflammatory pathways, and cytoprotective mechanisms in laboratory cell populations.ARA-290 10mg Product SpecificationsSupplied as 10mg lyophilized peptide powder. Store at -20°C in sealed, desiccated conditions. Purity ≥98% by HPLC/MS analysis. Reconstitution in sterile PBS or research-grade saline (1-5 mg/mL) recommended. Typical research application: 0.1-10 μM in cell culture protocols.ARA-290 Research Use Only DisclaimerThis product is intended exclusively for in vitro preclinical research. Not approved for human consumption, clinical application, or in vivo animal studies without institutional authorization. All handling must comply with biosafety and peptide handling guidelines.
