Buy 5-amino-1mq 50mg (25 tablets) Research Capsules OnlineThese compressed tablets deliver NNMT-inhibitory activity for sustained preclinical research workflows. Each tablet contains 50mg of the quinolinium-class selective NNMT antagonist, formulated for convenient dissolution and consistent distribution across multiple experiments without requiring volumetric pipetting or solvent adjustments.5-amino-1mq Mechanism & Enzyme SelectivityThe NNMT enzyme transfers methyl groups to nicotinamide via SAM-dependent catalysis. This inhibitor blocks that reaction through competitive binding, reducing cellular N1-methylnicotinamide and affecting NAD homeostasis. Preclinical studies confirm selectivity against related methyltransferases (COMT, DNMT, PRMT) at therapeutic concentrations, minimizing confounding effects in multi-target screening protocols.5-amino-1mq Established Preclinical LiteratureBioorganic & Medicinal Chemistry Letters (2019) published cell-based assays demonstrating NNMT inhibition in multiple tissue types (liver, muscle, adipose, kidney). Results showed dose-dependent NAD accumulation and altered metabolic gene expression patterns. Molecular Pharmacology (2020) characterized mechanism of action using recombinant NNMT protein and isothermal titration calorimetry.5-amino-1mq Research ApplicationsUsed in mitochondrial bioenergetics studies, cellular stress response models, and differentiation protocols. Researchers dissolve tablets in culture medium to examine NAD -linked signaling cascades, sirtuin activation, and metabolic reprogramming in laboratory cell systems. Tablet format eliminates solubility challenges and provides enhanced convenience.5-amino-1mq 50mg (25 tablets) Tablet Specifications & Reconstitution25-tablet container; each tablet = 50mg compound. Tablets dissolve readily in DMSO, ethanol, or aqueous buffers (pH 6.5-8.0) within 5-10 minutes. For cell culture: recommend 10-50 μM final concentration. Storage: -20°C in original sealed container, minimum 24-month stability.5-amino-1mq Research Use Only DisclaimerThese tablets are intended solely for in vitro preclinical investigation. Not intended for human consumption, animal studies, or clinical use. Researcher must ensure institutional approval and chemical safety compliance.
